China: Peking University_new Taxol treatment schedule for breast cancer

Breast Cancer Res Treat. 2010 Jun 26.
Weekly paclitaxel improved pathologic response of primary chemotherapy compared with standard 3 weeks schedule in primary breast cancer.

Taiwan pharmaceutical company, TTY BIopharm, acquired Japan drug maker (Shionogi) factory in Taiwan.

2010 Jun. 25 TTY announced that the acquired Shionogi factory in Taiwan will manufacture non-cancer drugs for a new TTY spin-off company and Shionogi in Japan as well. Meanwhile, TTY will invest the resources to upgrade the factory to comply with PIC/S regulation.

It's intrigued to know further details regarding TTY Biopharm strategy.

Taiwan: Chung Shan Medical University_The association of lung cancer and Human papillomavirus infection

Cancer. 2010 Jun 24.
Up-regulation of interleukin-17 expression by human papillomavirus type 16 E6 in nonsmall cell lung cancer.
http://www.ncbi.nlm.nih.gov:80/pubmed/20578176

Taiwan: National Cheng Kung University_How DNA 5'-cytosine-methyltransferases contributes lung cancer

Cancer Res. 2010 Jun 22. [Epub ahead of print]
Dysregulation of p53/Sp1 Control Leads to DNA Methyltransferase-1 Overexpression in Lung Cancer.
http://www.ncbi.nlm.nih.gov/pubmed/20570896

Taiwan: Tri-Service General Hospital;_ estrogen receptor alpha gene polymorphism reveals different role for Chinese and Caucasian women

Clin Cancer Res. 2010 Jun 22.
Diverse Associations between ESR1 Polymorphism and Breast Cancer Development and Progression.
http://www.ncbi.nlm.nih.gov/pubmed/20570923

Taiwan: National Taiwan University_a-fetoprotein as a indicator for therapeutic response of sorafenib, bevacizumab, or thalidomide in combination with

Cancer. 2010 Jun 22.
Early alpha-fetoprotein response predicts treatment efficacy of antiangiogenic systemic therapy in patients with advanced hepatocellular carcinoma.
http://www.ncbi.nlm.nih.gov:80/pubmed/20572033

Taiwan: National Yang-Ming University_Cancer of the Liver Italian Program is a better model for liver cancer prognosis

Cancer. 2010 Jun 15;116(12):3006-14.
Selecting an optimal staging system for hepatocellular carcinoma: comparison of 5 currently used prognostic models.
http://www.ncbi.nlm.nih.gov:80/pubmed/20564406

Taiwan: Tri-Service General Hospital_4 genes Methylation levels (,SOX1, PAX1, LMX1A, NKX6-1) link cervical cancer

Cancer. 2010 Jun 8.
Quantitative DNA methylation analysis detects cervical intraepithelial neoplasms type 3 and worse.
http://www.ncbi.nlm.nih.gov/pubmed/20564139

China: Huazhong University of Science and Technology_ cholangiocarcinoma stem cells markers

Int J Cancer. 2010 Jun 21.
CD133 and ALDH may be the molecular markers of cholangiocarcinoma stem cells.
http://www.ncbi.nlm.nih.gov/pubmed/20568110

China: Nanjing Medical University_ Manganese superoxide dismutase gene polymorphism with breast cancer?

Breast Cancer Res Treat. 2010 Jun 22.
Possible risk modifications in the association between MnSOD Ala-9Val polymorphism and breast cancer risk: subgroup analysis and evidence-based sample size calculation for a future trial.
http://www.ncbi.nlm.nih.gov/pubmed/20567899

China: Shanghai Jiao Tong University_progestin resistant endometrial carcinoma linked with EGFR level

Cancer. 2010 May 11.
Overexpressed epidermal growth factor receptor (EGFR)-induced progestin insensitivity in human endometrial carcinoma cells by the EGFR/mitogen-activated protein kinase signaling pathway.
http://www.ncbi.nlm.nih.gov/pubmed/20564127

China: Sun Yat-Sen University_ High-intensity focused ultrasound helps bone cancer treatment

Cancer. 2010 May 28.
Noninvasive treatment of malignant bone tumors using high-intensity focused ultrasound.
http://www.ncbi.nlm.nih.gov/pubmed/20564113

China: Second Military Medical University_ surgery is effective for spinal metastases

Cancer. 2010 May 13.
Health-related quality of life in patients with spinal metastases treated with or without spinal surgery: a prospective, longitudinal study.
http://www.ncbi.nlm.nih.gov/pubmed/20564089

China: Shanghai Medical College _Lung cancer patients between aged 45-60 years reveal better survival rate

Cancer. 2010 May 11.
Multicenter analysis of lung cancer patients younger than 45 years in Shanghai.
http://www.ncbi.nlm.nih.gov/pubmed/20564076

China: Nanjing Medical University_No linkage VEGF 936C>T polymorphism and breast cancer (11597 subjects)

Breast Cancer Res Treat. 2010 Jun 19.
VEGF 936C>T polymorphism and breast cancer risk: evidence from 5,729 cases and 5,868 controls.
http://www.ncbi.nlm.nih.gov/pubmed/20563637

Taiwan: A biotechnology group proposed under the cross-strait economy cooperation committee

Taiwan legislator, LAI Shyh-Bao, proposed certain biotechnology related businesses should be considered to be listed in "early harvest" negotiation of ECFA with China. This biotech taskforce structure could refer to similar function in TIFA rather than CEPA structure between China and Hong Kong.

Taiwan: Sinophar (Taiwan) signed Chinese medicine research cooperation agreement with Pekin University

2010, Jun., 21 The cross-strait conference of cooperation and development of Chinese medicine convened in XIAMEN unveiled 6 agreements between institutes, universities or firms. The most representative is agreement for Sinophar Pharmaceutical and Pekin University. The Sinophar relations with Pekin University could date back 2002 for certain proprietary herbal product developments. Details in Chinese:

北京大学中医药现代研究所中心、杏辉药品: 海峡两岸国药新药开发合作协议书
厦门大学医学院、台湾科技器材、厦门门科技精密器材: 中医亚健康数字化帮助诊疗系统开发合作协议
厦门海峡中医药合作发展中心、台湾中医诊断协会: 中医临床诊断工艺项目对接合作意向书
厦门大学生物医学研究院、台湾昌历实业: 台湾特色国药小叶匍萄的研究与开发合作协议
厦门海峡中医药合作发展中心、台湾红崴科技: 中医临床适宜工艺培训深度合作合议
厦门大学生物医学研究院、台湾南方开发: 牛樟芝现代化工艺应用与产业开发合作意向书

China: Guangzhou Medical College_A potential lung cancer biomarker

Carcinogenesis. 2010 Jun 16.
A functional variant (-1304T>G) in the MKK4 promoter contributes to a decreased risk of lung cancer by increasing the promoter activity.
http://www.ncbi.nlm.nih.gov:80/pubmed/20554746

Taiwan: Sinphar and Daito (Japan), drug makers cooperation

Sinphar Pharmaceutical Co., Ltd. of Taiwan signed a cooperative agreement with Daito Pharmaceutical (Japan) for development and manufacturing of breast cancer drugs. Detailed is not discosed. But, what it is apparent is that Japanese drug maker intends slash down production cost by offshore sourcing. This act is majorily prompted by Japan authority policy amended.

China: Fudan University_Non-ltumor parts biomarker is associated with intrahepatic metastasis, recurrence, and patient survival after hepatectomy

Oncologist. 2010 Jun 15.
High Expression of Macrophage Colony-Stimulating Factor-1 Receptor in Peritumoral Liver Tissue Is Associated with Poor Outcome in Hepatocellular Carcinoma After Curative Resection.
http://www.ncbi.nlm.nih.gov/pubmed/20551429

China: Chinese Academy of Science_3 cooperated teams (US/ Germany/ China) reveal chromosome 8q24 linked with prostate cancer

Cancer Epidemiol Biomarkers Prev. 2010 Jun 15.
Association between Genetic Variants in the 8q24 Cancer Risk Regions and Circulating Levels of Androgens and Sex Hormone-Binding Globulin.
http://www.ncbi.nlm.nih.gov/pubmed/20551303

China: University of Hong Kong_potential Head and neck tumor suppressor (metalloprotease family member ADAMTS9)

Cancer Res. 2010 Jun 15.
Extracellular Protease ADAMTS9 Suppresses Esophageal and Nasopharyngeal Carcinoma Tumor Formation by Inhibiting Angiogenesis.
http://www.ncbi.nlm.nih.gov/pubmed/20551050

China: Huazhong University of Science and Technology_A potential biomarker (X-ray repair cross-complementing 1)for breast cancer

Breast Cancer Res Treat. 2010 Jun 13.
A functional -77T>C polymorphism in XRCC1 is associated with risk of breast cancer.
http://www.ncbi.nlm.nih.gov/pubmed/20549339

China: Sun Yat-sen University_A biomarket or therapy (MicroRNA-125b) for bladder cancer

Int J Cancer. 2010 Jun 14.
MicroRNA-125b suppresses the development of bladder cancer by Targeting E2F3.
http://www.ncbi.nlm.nih.gov/pubmed/20549700

China: Disease Control and Prevention of Shenzhen_ATM C. 1066-6T biomarker for breast cancer under scrutinizing

Breast Cancer Res Treat. 2010 Jun 11.
Lack of association between ATM C.1066-6T > G mutation and breast cancer risk: a meta-analysis of 8,831 cases and 4,957 controls.
http://www.ncbi.nlm.nih.gov:80/pubmed/20544271

Taiwan: Veteran General Hospital Taipei establishes the heart valves bank

2010, Jun., 14 Beside of Britain, Queensland, Brazil, Germany, an collaboration between Taiwan local biotech company and Veteran General Hospital for banking donated heart valves and vascular tissues is announced. It is estimated to complete health authority examination and approval by the end of this year.

Taiwan: Chang Gung Hospital_multinational trial_the heart side effect on herceptin-treated breast cancer patients

J Clin Oncol. 2010 Jun 7.
Longer-Term Assessment of Trastuzumab-Related Cardiac Adverse Events in the Herceptin Adjuvant (HERA) Trial.
Even the low incidence rate of cardiac disorder (5.1%) after long term herceptin treatment, it appears higher than control subjects. http://www.ncbi.nlm.nih.gov/pubmed/20530280

China: Changning Maternity and Infant Health Hospital_A possible marker for early cervical cancer

Cancer Res. 2010 Jun 8.
HPV16 E2 Is an Immediate Early Marker of Viral Infection, Preceding E7 Expression in Precursor Structures of Cervical Carcinoma.
http://www.ncbi.nlm.nih.gov/pubmed/20530671

China: Peking Union Medical College_10 SNP(s) linked Caucasians colon cancer but 5 out of 10 found in Chinese patients

Cancer Epidemiol Biomarkers Prev. 2010 Jun 8.
Risk of Genome-Wide Association Study-Identified Genetic Variants for Colorectal Cancer in a Chinese Population.
http://www.ncbi.nlm.nih.gov/pubmed/20530476

China: Chinese Academy of Medical Sciences_multinational trial of Ixabepilone Plus Capecitabine on breast cancer patients

J Clin Oncol. 2010 Jun 7.
Randomized Phase III Trial of Ixabepilone Plus Capecitabine Versus Capecitabine in Patients With Metastatic Breast Cancer Previously Treated With an Anthracycline and a Taxane.

China: Jiao Tong University_ Necrolytic Migratory Erythema Associated With Glucagonoma Syndrome

J Clin Oncol. 2010 Jun 7. http://www.ncbi.nlm.nih.gov/pubmed/20530273

Taiwan_Herbal treatment for epilepsy

Taiwanese researcher found one common herb extract appears therapeutic effect for eplipsy. Moreover, no dopamine blocker-related adverse effects were found for this treatment. Two-year follow-up results presented.

National Taiwan University_ Factor 9 treatment on Hemophilia type B patient

2010, Jun., 10 Taiwan National pharmaceutical & Biotech project announced sponsored technology regarding engineered high potent (rather than long circulation) factor 9 for treatment of hemophilia.

National Taiwan University_The correlation of microRNAs and genes expression signature with lung cancer survival

2010, Jun., 10 Taiwan National pharmaceutical & Biotech project announced sponsored technology regarding special signature expression predict post surgery lung cancer patients survival rate.

National Taiwan University_The correlation of microRNA alteration and enterovirus infection

2010, Jun., 10 Taiwan National pharmaceutical & Biotech project announced sponsored technology for cooperation. Research characterized the function of microRNA 141 in the virus infections, including EV71, polivirus 3 and coxsackievirus B3

As turning into the largest CRO, WuXi PharmaTech is struggling !

June 7, 2010 : The major shareholder, Jana Partners rejects Charles River Purchase of China’s WuXi. Jana head,Barry Rosenstein, said “Even if the contemplated benefits can ultimately be realized, we believe that the high cost, significant integration risks and inopportune timing simply make the proposed acquisition the wrong path for Charles River shareholders.”

Date backs to 2008, Covance surrendered a joint venture plan with WuXi.

Shanghai Jiao-Tong University_how hypoxia regulated lectins

Carcinogenesis. 2010 Jun 4.
Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells.
http://www.ncbi.nlm.nih.gov/pubmed/20525878

Tianjin Medical University_significant correlation between breast Ca & GSTP1

Breast Cancer Res Treat. 2010 Jun 5.
Glutathione S-transferase P1 Ile105Val polymorphism and breast cancer risk: a meta-analysis involving 34,658 subjects.

Data shows that Ile105Val polymorphism increases the susceptibility to breast cancer in Asian population.

Chinese University of Hong Kong_

Breast Cancer Res Treat. 2010 Jun 5. [Epub ahead of print]
Diagnosing breast lesions by fine needle aspiration cytology or core biopsy: which is better?
http://www.ncbi.nlm.nih.gov/pubmed/20526738

Harbin Medical University_

Breast Cancer Res Treat. 2010 Jun 6.
Evidence on the association between NQO1 Pro187Ser polymorphism and breast cancer risk in the current studies: a meta-analysis.

Data shows this polymorphism is more significant associated with breast cancer in Caucasians rather than in Asians
http://www.ncbi.nlm.nih.gov/pubmed/20526805

National Taiwan University_microRNA regulated protein is associated with liver cancer

Carcinogenesis. 2010 Jun 4.
Lin-28B expression promotes transformation and invasion in human hepatocellular carcinoma.
http://www.ncbi.nlm.nih.gov:80/pubmed/20525879

Harbin Pharmaceuticals acquired Pfizer animal vaccine biz

Pfizer sells animal vaccine business (a deal worth of 50 million U.S. dollars) to Harbin Pharmaceuticals

09:16, June 01, 2010

http://english.peopledaily.com.cn/90001/90778/90860/7007156.html

Nanjing Medical University_HCC with IL12 polymorphisms

Int J Cancer. 2010 Jun 2.

IL12 polymorphisms, HBV infection and risk of hepatocellular carcinoma in a high-risk Chinese population.

Fudan University, Shanghai_HCC prognostic marker

Int J Cancer. 2010 Jun 2.

Expression and prognostic significance of placental growth factor in hepatocellular carcinoma and peritumoral liver tissue.

Shanghai Jiao Tong University_HER2 codon 655 for Breast CA??

Breast Cancer Res Treat. 2010 Jun 4. [Epub ahead of print]
Lack of association between HER2 codon 655 polymorphism and breast cancer susceptibility: meta-analysis of 22 studies involving 19,341 subjects

http://www.ncbi.nlm.nih.gov:80/pubmed/20524057