Meta-analysis of B vitamin supplementation on plasma homocysteine,
cardiovascular and all-cause mortality
Background & aims Clinical Nutrition Available online 29 May 2012 Results from randomized controlled trials
(RCT) of B vitamin supplementation on risk of cardiovascular disease (CVD) were
inconclusive. The aim of the present study was to systematically review the
effects of B vitamin supplementation on plasma homocysteine (Hcy),
cardiovascular and all-cause mortality in RCT.
Methods RCT publications on the effect of B vitamin
supplementation on plasma Hcy, cardiovascular and all-cause mortality were
searched from PubMed and web of science database. Data were independently
abstracted by 2 investigators using a standardized protocol. The results were
pooled with a fixed-effects model using Stata software. Results Data from 19 studies including 47921participants were analyzed using a fixed-effects model. The overall relative risks with 95% confidence intervals of outcomes for patients treated with B vitamin supplementation compared with placebo were 0.98 (0.94–1.03) for CVD, 0.98 (0.92–1.05) for coronary heart disease (CHD), 0.97 (0.90–1.05) for myocardial infarction (MI), 0.88 (0.82–0.95) for stroke, and 0.97 (0.91–1.02) for cardiovascular death, 0.99 (0.95–1.04) for all-cause mortality. Blood Hcy levels were decreased in all included RCTs.
Conclusions B vitamin supplementation has a significant protective effect on stroke, but none on the risk of
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