嬰兒異位性皮膚炎 與 塑化劑 (n-butyl benzyl phthalate,BBP)關聯

Prenatal Exposure to Butylbenzyl Phthalate Linked to Eczema   Last Updated: June 27, 2012. Prenatal exposure to butylbenzyl phthalate, as assessed by increased concentrations of monobenzyl phthalate in the urine, is associated with an increased risk of early-onset eczema in offspring, according to a study published online June 26 in Environmental Health Perspectives. WEDNESDAY, June 27 (HealthDay News) -- Prenatal exposure to butylbenzyl phthalate (BBzP), as assessed by increased concentrations of monobenzyl phthalate (MBzP) in the urine, is associated with an increased risk of early-onset eczema in offspring, according to a study published online June 26 in Environmental Health Perspectives. Allan C. Just, Ph.D., from Columbia University in New York City, and colleagues measured MBzP in the urine of 407 African-American and Dominican women during the third trimester of pregnancy. The women were later asked whether their child had ever been diagnosed with eczema, and blood samples from the children were examined for allergens at age 24, 36, and 60 months. The researchers found that over 99 percent of urine samples contained MBzP. At 24 months, 30 percent of children had developed eczema, although eczema was much more common in African-Americans than Dominicans (48 versus 21 percent). After adjusting for urine-specific gravity, sex, and race/ethnicity, increasing MBzP levels were associated with an increased risk of developing early-onset eczema by 24 months (relative risk, 1.52 for an interquartile range increase in log MBzP concentration). The association was not affected by seroatopy, and MBzP did not correlate with allergic sensitization. "Prenatal exposure to BBzP may influence the risk of developing eczema in early childhood," Just and colleagues conclude. "The association appeared to be primarily among those with early-onset eczema, reported by 24 months of age."  
References.....

名稱	用途	致癌性	生殖毒性	*內分泌干擾物質 (環境荷爾蒙)
DEHP Di-(2-ethylhexyl) phthalate 鄰苯二甲酸 二(2-乙基己基)酯	食品包裝 醫療器材 建築材料 塑化劑	對動物有 WHO-IARC: 2B	動物：有 人類：研究中	是
BBP Butyl benzyl phthalate 鄰苯二甲酸 丁基苯酯	建築材料(含PVC) 人造皮革 汽車內飾 塑化劑	對動物有 WHO-IARC: 3	動物：有 人類：研究中	是
DBP Di-n-butyl phthalate 鄰苯二甲酸 二丁酯	食品包裝 乳膠黏合劑 溶劑	無足夠科學證據證明 WHO-IARC:無	動物：有 人類：研究中	是
DINP Diisononyl phthalate 鄰苯二甲酸 二異壬酯	鞋底 建築材料 塑化劑	對動物有 WHO-IARC:無	動物：不明顯 人類：研究中	不是
DIDP Diisodecyl phthalate 鄰苯二甲酸 二異癸酯	電纜線 膠鞋 地毯黏膠 橡膠襯墊	無足夠科學證據證明 WHO-IARC:無	動物：不明顯 人類：研究中	不是
DnOP Dioctyl phthalate 鄰苯二甲酸 二辛酯	地板膠 聚乙烯磁磚 帆布 塑化劑	無足夠科學證據證明 WHO-IARC:無	動物：不明顯 人類：研究中	不是
DIBP Di-isobutyl phthalate 鄰苯二甲酸 二異丁酯	油漆 紙漿 紙板 接著劑 塑化劑 黏度調整劑	無足夠科學證據證明 WHO-IARC:無	動物：不明顯 人類：研究中	不是
DEP Diethyl Phthalate 鄰苯二甲酸 二已酯	溶劑 護理用品 油墨	無足夠科學證據證明 WHO-IARC:無	動物：有 人類：研究中	是
DMP Dimethyl phthalate 鄰苯二甲酸 二甲酯	溶劑 個人衛生用品 護理用品 油墨	無足夠科學證據證明 WHO-IARC:無	動物：不明顯 人類：研究中	不是

Source: TFDA & 塑化劑DEHP參考資料(醫療衛生人員版)

see also... 塑化劑 (di-ethylhexyl phthalate, DEHP) 與 幼兒肥胖 高度相關 !!