Scientists discover Eya1 enzyme control of pulmonary barrier integrity

Published on July 3, 2012  Scientists have provided the first evidence that an enzyme called Eya1 protein phosphatase is a critical regulator of lung function and that this may have broad implications for sufferers of a variety of pulmonary diseases. "Identification of the role of Eya1 in establishing pulmonary tight junction and barrier integrity could have a significant impact on asthma, chronic obstructive pulmonary disease, and acute respiratory distress syndrome, all diseases characterized with disruptions in permeability," said Ahmed El-Hashash, PhD, investigator at The Saban Research Institute of Children's Hospital Los Angeles and assistant professor at the Keck School of Medicine.  Proper formation of lung epithelium is essential to life. The normal growth and functioning of the lung depends on the formation of tight junctions between adjacent cells making up the alveolar epithelial sheet, a thin layer of tissue separating neighboring alveoli. Alveoli are the site of gas exchange between the lung and blood vessels. Loss of these tight junctions alters the exchange of oxygen and carbon dioxide. Permeability dysfunction has been implicated in both acute lung injury and acute respiratory distress syndrome, a life-threatening lung condition that prevents adequate oxygen from getting from the lungs and into the blood.