July
3, 2012 in
Medical research A study conducted at the University of Granada
hasdemonstrated that ibuprofen –a non-steroidal anti-inflammatory drug
(NSAID)– has beneficial effects on bone repair after afracture or following
bone surgery. Custom Antibodies-Absea - Quality rat and murine monoclonals, polyclonals,
antibody purification - www.absea-antibody.com In vitro tests demonstrated that
–unlike other NSAIDs– when a therapeutic dose of ibuprofen is administered, it
has no negative effects on the proliferation and synthesis of obsteoblast
osteocalcin, a cell which is directly involved in the formation and
regeneration of bones. Osteoblast cells are bone cells that synthesize the bone
matrix. Consequently, osteoblasts play a major role in bone development,
growth, maintenance and repair. In an article recently published in the Journal
of Bone and Mineral Metabolism, the University
of Granada researchers
report the positive effects of ibuprofen on bone repair. The researchers are
members of the research group BIO277, which studies the effects of different pharmacological
and non-pharmacological therapies on obsteoblast cells. The primary author of
this article, Concepción Ruiz Rodríguez, a professor at the University of
Granada Nursing Department states that "up to date, we had little
information on the effects of ibuprofen on osteoblast cells". The University of Granada study demonstrates that a
therapeutic dose of ibuprofen (5-25µm.) does not inhibit the proliferation and
synthesis of osteocalcinin the MG-63 cell line. However, when higher doses are
administered (>25 µm.) they may activate other cells, which might explain
theexpression of membrane markers and the decrease in the phagocytic capacity. Provided
by University of Granada
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