利用愛滋病毒 (HIV)治療癌症 !!!

AIDS may one day be used to cure cancer, say researchers Posted on September 2, 2012 By Global Post Physical Health AIDS may one day be used to help cure cancer and other diseases say French researchers in a new paper. A CNRS team of scientists said that they have been able to select a mutant protein in the HIV virus and then add it, along with a cancer drug to tumor cells. According to Science Daily, adding the mutant protein improves treatment with the cancer drug 1/300 the normal dosage levels. AIDS may one day be used to help cure cancer and other diseases say French researchers in a new paper. The finding was made with the knowledge that the HIV virus, which causes AIDS, multiplies using human cells by putting its own genetic material into the host cells' genome.The virus has been so difficult to treat because it constantly mutates and multiplies.Yet, for that reason, researchers believe they can rechannel the virus for therepeutic uses."Through HIV multiplication, [we] selected a "library" of nearly 80 mutant proteins and tested them on tumor cells in the presence of an anticancer drug. The results have enabled us to identify a dCK variant that is more effective than the wild-type (non-mutated) protein, inducing the death of tumor cells in culture," said the researchers in a statement, reported Counsel and Heal."The possibility of reducing the doses of anticancer drugs would palliate the problems posed by their components' toxicity, reduce their side-effects and, most importantly, improve their effectiveness."Complicated terminology aside, adding the fast-moving HIV cells helps to outcompete and finally eliminate cancer cells—then the problem likely is getting rid of the HIV.

新研究称艾滋病病毒有助于对抗癌症 发布时间：2012-9-6 来源：药品资讯网信息中心 艾滋病是威胁人类健康的一大杀手，让其"弃暗投明"帮助科学家对抗癌症，听起来似乎是件完全不可能的事情。据每日科学网8月29日报道，法国国家科学研究院（CNRS）的科学家日前就独辟蹊径，让其成为了现实。利用艾滋病病毒（HIV）的复制机制，该机构的研究人员已经培育出了一种突变体蛋白。该物质能极大提高抗癌药物的功效，在与抗癌药物联合使用时，药物剂量减至先前的1/300即可达到同样的疗效。相关论文发表在8月23日出版的《公共科学图书馆—遗传学》上。该发现有望在癌症和其他疾病的治疗中发挥重要作用。HIV通过大量复制病毒将自己的遗传物质插入宿主细胞的方式来进行繁殖。其显著特征是，HIV通过不断发生变异并产生多种不同突变蛋白（突变体）来进行繁殖，这种特性使其能够在复杂多变的环境中生存。迄今为止，还没有任何一种药物能够将其彻底杀灭。法国国家科学研究院的科学家反其道而行之，提出了使用HIV的策略来治疗其他疾病，尤其是癌症的设想。为了验证这一想法，他们首先通过向HIV基因中插入一种人类基因对其进行改造。这种基因能够促成脱氧胞苷激酶(dCK)的产生。脱氧胞苷激酶是催化抗病毒和抗肿瘤药物在人体内合成其单磷酸盐的关键酶，是激活抗肿瘤药物的关键所在。不少病毒或癌细胞对药物的抗药性都与人体细胞内脱氧胞苷激酶的失活相关。因此，近几年来全世界的科学家们一直试图通过增加脱氧胞苷激酶的活性、提高其效率的方式实现对肿瘤的抑制。根据HIV的繁殖方式，该研究团队建立一个包括近80个艾滋病病毒突变的突变体库，并结合抗癌药物对其进行实验以确定其功效。结果发现，这些突变体在识别脱氧胞苷激酶方面比传统的未变异蛋白更有效。当抗癌药物与这些突变体蛋白联合使用时，在剂量上只需原先的1/300即可达到同样的疗效。这种方法不但能够降低大剂量抗癌药物在使用时所有可能产生的副作用，还能极大地提高效率。下一步，研究人员还将在动物实验中对单独的突变体蛋白进行测试。研究人员称，除治疗癌症外，类似的疗法在抗病毒治疗中也具有一定潜力。