美食品添加dimethylbutylamine惹疑慮

UK Anti-Doping warning: New supplement ingredient 1, 3-dimethylbutylamine (DMBA) 27/04/2015 UKAD Science and MedicineUKAD Science and Medicine UK Anti-Doping cautions athletes and players in the UK to be aware of the prohibited substance 1, 3-dimethylbutylamine (DMBA) following its identification in a number of supplement products. A recent study by Cohen and colleagues (2015) identified the presence of the stimulant in a range of supplements that are marketed to increase weight loss, enhance brain function, or to be used as a pre-workout supplement. DMBA has a similar chemical structure to the prohibited and potentially dangerous stimulant methylhexaneamine and appears to be a replacement for methylhexaneamine in supplement formulations. A previous warning was issued in 2012.Supplement manufacturers have been found to label products containing DMBA using one or more of the following names: AMP citrate, 1,3-dimethylbutylamine citrate, 4-amino-2-pentanamine, pentergy, 4-amino-2-methylpentane citrate, 4-AMP, 2-amino-4-methylpentane, and 4-methyl-2-pentanamine.Athletes should avoid all products that contain this substance as its use could be detrimental to health and lead to an Anti-Doping Rule Violation (ADRV) following an In-Competition test. The safety of DMBA is also unknown since the stimulant has never been studied in humans. All athletes are advised to be vigilant in using any supplement. No guarantee can be given that any particular supplement is free from prohibited substances. 1,3-Dimethylbutylamine (DMBA) is a stimulant that is a structural analog of methylhexanamine (DMAA) in which a butyl group replaces the amyl group. making it methylhexbutylanamine. It has been identified as an unapproved ingredient in some over-the-counter dietary supplements,[2][3] in which it is used in an apparent attempt to avoid laws prohibiting the use of DMAA. There are no known safety studies on DMBA and its health effects are entirely unknown.

FDA Under section 413 of the Act (21 U.S.C. 350b), a dietary supplement that contains a new dietary ingredient (i.e., a dietary ingredient not marketed in the United States before October 15, 1994) shall be deemed adulterated under section 402(f) of the Act (21 U.S.C. 342(f)) unless it meets one of two requirements:

1. The dietary supplement contains only dietary ingredients that have been present in the food supply as an article used for food in a form in which the food has not been chemically altered; or

2. There is a history of use or other evidence of safety establishing that the dietary ingredient when used under the conditions recommended or suggested in the labeling of the dietary supplement will reasonably be expected to be safe and, at least 75 days before being introduced or delivered for introduction into interstate commerce, the manufacturer or distributor of the dietary ingredient or dietary supplement provides FDA with information, including any citation to published articles, which is the basis on which the manufacturer or distributor has concluded that a dietary supplement containing such dietary ingredient will reasonably be expected to be safe.