《自然》高油飲食 “促” 癌轉移: CD36 (fatty acid receptor) 成關鍵 !!!

研究：吃巧克力恐讓癌細胞擴散 原因竟是裡面的這個成分！ 2016-12-0911:50 〔即時新聞／綜合報導〕許多人都認為吃巧克力將讓心情變好，但這恐怕不適用在癌症病患身上。根據英媒《每日郵報》報導，西班牙巴塞隆納的研究機構，週三於《自然》科學雜誌發表最新研究成果，指癌症病患如食用巧克力、餅乾、某些糖果等含有棕櫚油的食物，將可能導致癌細胞進一步擴散。研究人員分析棕櫚油中的成分，發現其會刺激人體內一種名為「CD36」的蛋白質，這種蛋白質將會進一步影響惡性腫瘤的擴散及發展。研究人員在末期口腔、皮膚、卵巢、膀胱、肺及乳腺癌的腫瘤細胞膜上，均發現了「CD36」蛋白質。研究人員接著在白老鼠身上注入人類的口腔癌細胞，發現癌細胞若接觸到CD36時，便會有擴散的情況發生。研究團隊因此推測，若能用抗體阻斷CD36，將有望阻止癌細胞轉移。

Targeting metastasis-initiating cells through the fatty acid receptor CD36   The fact that the identity of the cells that initiate metastasis in most human cancers is unknown hampers the development of antimetastatic therapies. Here we describe a subpopulation of CD44bright cells in human oral carcinomas that do not overexpress mesenchymal genes, are slow-cycling, express high levels of the fatty acid receptor CD36 and lipid metabolism genes, and are unique in their ability to initiate metastasis. Palmitic acid or a high-fat diet specifically boosts the metastatic potential of CD36+ metastasis-initiating cells in a CD36-dependent manner. The use of neutralizing antibodies to block CD36 causes almost complete inhibition of metastasis in immunodeficient or immunocompetent orthotopic mouse models of human oral cancer, with no side effects. Clinically, the presence of CD36+ metastasis-initiating cells correlates with a poor prognosis for numerous types of carcinomas, and inhibition of CD36 also impairs metastasis, at least in human melanoma- and breast cancer-derived tumours. Together, our results indicate that metastasis-initiating cells particularly rely on dietary lipids to promote metastasis.

Source : Pascual, G. et al. Nature http://dx.doi.org/10.1038/nature20791 (2016).