October 13, 2011 Shares of SANUWAVE Health Inc (OTC:SNWV) rose 20.9% to $2.14 +0.37 after the company announced publication of research which investigated the molecular changes of dermaPACE extracorporeal shock wave technology (ESWT) compared with hyperbaric oxygen therapy (HBOT) in diabetic foot ulcers. The study, titled Molecular Changes in Diabetic Foot Ulcers, by Ching-Jen Wang, M.D. of the Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine in Kaohsiung, Taiwan, appeared in the online edition of the European peer-reviewed journal Diabetes Research and Clinical Practice as an ePublication ahead of print. dermaPACE showed statistically significant increases in angiogenic and tissue regenerative molecular changes over HBOT in diabetic foot ulcers. dermaPACE demonstrated significant increases in angiogenesis (vWF, VEGF and eNOS) and cell proliferation (PCNA and EGF) and decreases in cell apoptosis (TUNEL), leading to tissue regeneration and wound repair (p<0.05), whereas the molecular changes after HBOT were not statistically significant. The study consisted of 39 patients (44 ulcers) in the ESWT group and 38 patients (40 ulcers) in the HBOT group, with similar demographic characteristics. The ESWT group received dermaPACE procedures twice per week for a total of six procedures over three weeks. The HBOT group received hyperbaric oxygen therapy daily for a total of 20 treatments, each lasting 90 minutes. Biopsies were performed from the periphery of the ulcer before and after treatment. Some recent trading activity prompted officials to look into the activities of one market maker in particular after Tuesday's session. It is unclear if the situation has been resolved, but there are definintely eyeballs monitoring the trading activities of the firm and trading action seemed to go much more smoothly on Wednesday.
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