可能被污染 奥地利建议更换诺华集团流感疫苗

Novartis Flu Vaccine Ban: Who Wins? By James Brumley, InvestorPlace Contributor  |  Oct 31, 2012, 8:49 am EDT If Novartis (NYSE:NVS) were a Looney Tunes character, what happened to it last week would be the equivalent of an anvil landing on its head. Only in this case, it's no laughing matter. Real investors lost real money and, worse, real lives may have been put at risk. Two of the Switzerland-based pharmaceutical company's flu vaccines — Agrippal and Fluad — were banned in seven countries — Spain, Canada, Switzerland, Austria, Germany, Italy, and France — after small particles were found to have developed in the vaccine's vials. Still, while it's a high-profile mistake, the impact of the alleged stumble may be far smaller than the market has assumed. Let's take a further look.

The Foul-Up(s) Having one of your products banned in one country due to safety concerns is never a good thing. Having one of your products banned in seven countries (with perhaps more on the way) can be downright miserable. The company doesn't yet know why the particles formed, or even what they are (other than protein clumps). The governing bodies that banned the vaccines don't even know if they're dangerous or not … but nobody's taking any chances. If this seems a little familiar, that's because Novartis AG is the same company that was forced to stop production of its migraine medicine Excedrin for a while in the middle of the year when quality concerns were raised. The company also froze production of one its pet products as well as an athlete's foot therapy — also thanks to quality issues. It was the two troubled flu vaccines, however, that put the kibosh on the stock last week, knocking 4% off its value after news of the bans started to come out. It's all academic at this point, though. What investors really want to know, now that the damage is done, is how much Novartis loses — and who wins.

Now What? Believe it or not, Novartis' entire vaccine library only generates about 5% of its annual sales. That's "only" $2.8 billion of the $57.5 billion in revenue the pharmaceutical maker has generated through the past four quarters. And only about a quarter of its vaccine revenue stems from flu shots, so there's only $718 million in jeopardy with the ban on Agrippal and Fluad in effect. Point being, the fiscal risk here is actually pretty small; the company's reputation is in more jeopardy. Still, that's $718 million up for grabs. Who's waiting in the wings to win that business?

Potential Winners The Favorite: Europe isn't necessarily aiming to be protectionist, but it makes sense that the region would fill Novartis' shoes with another local pharma manufacturer. That puts Sanofi (NYSE:SNY) and GlaxoSmithKline (NYSE:GSK) at the top of the list.French corporation Sanofi makes an almost confusing number of influenza vaccines, including Intanza (IDflu), Panenza, Humenza, Fluzone and Vaxigrip (Mutagrip), with each aimed at a slightly different scenario based on age and need. UK-based GlaxoSmithKline makes the popular Fluarix vaccine.Contenders: While European manufacturers have the inside track, that's not to say an American company can't squeeze its way in. Indeed, depending on the demand and perceived need for a flu vaccine this year, the medical community (and governing bodies) may welcome any and all sources for flu shots. That puts Baxter International's (NYSE:BAX) Preflucel in the mix, as well as Merck (NYSE:MRK).Sure, Merck isn't exactly the first name you think of when you think of flu shots, but they're in the game as a distributor of Afluria — made by CSL Biotherapies, a subsidiary of CSL Limited (NYSE:CSL). Most investors may not realize it, but CSL is actually one of the biggest flu vaccine manufacturers in the world. It just doesn't market much of anything under its own name.A Dark Horse: While CSL Limited is one of the more compelling ways to play Novartis' stumble, it's also only available via the Australian stock exchange, and therefore may be out of reach for some investors. The next-best way to tip-toe into the influence vaccine market may be through AstraZeneca (NYSE:AZN).Like Merck, AstraZeneca isn't exactly a high-profile name in the flu vaccine world. Its Medimmune subsidiary makes the FluMist spray vaccine, however, which was approved for sale in Europe last year.

The Last Word While these are all tempting picks, capitalizing on a company's mistake by buying shares of another company may not be worth the trouble in this case. It's very likely the five companies or partnerships discussed here could simply split the $718 million that Novartis AG doesn't look like it will be able to earn this flu season. That isn't a big amount to begin with and it won't even be a drop in the bucket if it's split between the five names in the global flu vaccine race.

 发布时间：2012-10-30 来源：药品资讯网信息中心 由于诺华制药集团的流感疫苗可能被污染,奥地利建议该国医生改选其它制药公司生产的疫苗。周四(10月25日)奥地利卫生部部长表示,此次涉及到的是在奥地利国内通过审批的三种疫苗,分别是Fluad、Sandovac和Optaflu。奥地利医疗安全部门表示:"在还没有证据表明对患者有危害之前,这是一种预防措施。"奥地利卫生部一名发言人Sigrid Rosenberger称,诺华集团已经了解到了其产品在奥地利存在的问题,目前不同的机构正在对此进行检审。在确定疫苗所含成分没有问题之后,诺华制药集团的鉴定书才递交给奥地利卫生部。现在奥地利打算自行对诺华集团的流感疫苗进行审检,审检时间可能持续3周。Rosenberger表示,幸运的是现在还不是流感高发期,疫苗完全没有开始接种。奥地利药品管理机构AGES PHarmMed主席Marcus Müllner在接受奥地利媒体采访时表示,目前已经有约4.5万盒Sandovac疫苗被运往各地,相关机构正在努力确认这些疫苗身在何处。现在奥地利严令禁止使用这些疫苗,Optaflu和Fluad还未开始运送。