利用打疫苗減肥 的夢想快實現了?!

 Experimental vaccine knocks the weight off flabby mice    July 9, 2012 | By John Carroll The quest to find a safe, effective obesity treatment that could be used by the flabby masses led one team of investigators to try out a new vaccine approach that proved promising in a preclinical mouse study. The scientists created two versions of modified somatostatin, a peptide hormone, and found that the vaccines knocked off an average of 10% of the fat off of the rodents in four days. And they say the same approach is worth trying out in humans. The team at Braasch Biotech–which has been collaborating with investigators at the Jackson Laboratory--was working with the knowledge that somatostatin puts a brake on the action of growth hormone and insulin-like growth factor (IGF-1), which are known to rev up metabolism and spur weight loss. The vaccines generated antibodies to somatostatin, which eased the brake on those two targets and helped lead to the weight loss.  

Somatostatin Vaccines Can Keep The Body Slim Around the world obesity and obesity-related diseases are on the rise. Now, researchers have found that two somatostatin vaccinations, JH17 and JH18, can effectively keep the body slim. The study is published in the Journal of Animal Science and Biotechnology. According to Keith Haffer from Braasch Biotech LLC, both growth hormone (GH) and insulin-like growth factor (IGF-1) increase metabolism and result in weight loss. However, a peptide hormone called somatostatin inhibits the action of GH and IGF-1. They found that vaccination with modified somatostatin effectively removes this inhibition by stimulating the body to generate antibodies to somatostatin.  In the six week study, the team tested the vaccinations in two groups of diet-induced obese mice. 10 mice received the vaccinations, while the other 10 mice (the control group) received saline injections. The vaccinations were administered twice - at the start of the study followed by a booster vaccination on day 22. The researchers found that mice who received modified somatosatin had a 10% reduction in body weight just four days after the initial injection. This did not happen in the control group. According to the researchers, at week six, the vaccines were shown to have induced antibodies to somatostatin and significantly reduced body weight, sustaining a 10% lower body weight, without affecting normal levels of the growth hormone IGF-1, or insulin levels.