Friday, December 30, 2016

CrownBio (中美冠科) 設美國子公司 加入新商機 (非人靈長類實驗; CVMD藥效評估)


攜手美研究中心 中美冠科藥效實驗能力躍進 2016-12-29 14:07聯合晚報 記者黃淑惠╱台北報導 中美冠科-KY6554將與全美最大靈長類動物研究中心進行策略合作攜手新伊比利研究中心強化模型開發與測試能力,隨著布局強化利多加持,29日盤中股價一度來到48.3元、漲幅3.2%。中美冠科專精腫瘤及代謝疾病研究提供臨床前技術服務CRO生技服務;是全球首家運用生物資訊學方法對大量PDX模型資料進行分析,進而找出預測藥物有效性特徵指標(Biomarker)的跨國公司。中美冠科執行長魏京平(Jean-Pierre Wery)與路易斯安那州州長John Bel Edwards,日前共同宣布冠科將與全美最大靈長類動物研究中美國路易斯安納州新伊比利研究中心策略合作,此合作案將大幅提升冠科的心血管代謝類疾病服務與藥效評估模型設計的業務發展,冠科將在路易斯安納州設立100%持有的子公司,為公司營運再擴充據點。新伊比利亞研究中心隸屬於路易斯安那大學拉法葉分校,專門從事非人靈長類實驗動物的應用和基礎研究管理,目前是也全美最大的國立靈長類動物研究中心,且該研究中心也通過AAALACOLAWUSDA等重要的認證。魏京平表示,新伊比利亞研究中心的眾多研究設施可以強化冠科-KY對於藥效學實驗和模型開發實驗與測試能力。新伊比利亞研究中心董事Francois Villinge指出,新伊比利亞中心擁有研究和分析的專業技能和基礎設施,這無疑可以協助冠科-KY更快速地回應其全球化客戶的需求。冠科-KY全球戰略合作及市場拓展部高級副總裁Laurie Heilmann表示,新伊比利亞中心非靈長類動物模型設計與服務能力的提升,將為公司現有客戶和未來客戶提供一整套的解決方案,讓客戶更專注其內部臨床前藥物開發。

Crown Bioscience selects New Iberia Research Center for pharmaceutical facility Posted: Dec 29, 2016 4:04 AM Updated: Dec 29, 2016 4:04 AM  NEW IBERIA, La. - Today, Gov. John Bel Edwards and Crown Bioscience Inc. CEO Jean-Pierre Wery announced the company will establish a pharmaceutical research and development facility in Louisiana at the New Iberia Research Center. The expansion project for the global drug discovery and development company will enable CrownBio to advance treatments for cardiovascular and metabolic disease research (CVMD research).   CrownBio will coordinate its research efforts with the New Iberia Research Center, an affiliate of the University of Louisiana at Lafayette, which specializes in the management of nonhuman primates for applied and basic research. At the research center, CrownBio will make a $1 million capital investment and create 10 new direct jobs with an average annual salary of $70,000, plus benefits. Louisiana Economic Development estimates the project will result in an additional 14 new indirect jobs.  "This project provides an excellent example of how Louisiana's higher education system is leveraging its strengths to attract new investment in bioscience to our state," Gov. Edwards said. "Sophisticated pharmaceutical research performed in a sensitive and progressive manner is essential for our state, nation and world to combat illnesses and diseases that continually pose new challenges. We're proud that this important work will be taking place in our state and will build upon the resources of UL Lafayette and the New Iberia Research Center."  Headquartered in Santa Clara, California, Crown Bioscience formed in 2006 and operates research campuses in China, the U.K., San Diego and Indianapolis. The company's leadership - including Executive Chairman and Chief Technology Officer Guo-Liang Yu, CEO Jean-Pierre Wery and President and Chief Strategy Officer Alex Wu, possesses decades of experience in the global biotech and pharmaceutical industry. The New Iberia Research Center (NIRC) was crucial in the company's decision to come to Louisiana.  "We chose to expand in Louisiana, and specifically the NIRC, because of the growing biomedical science community there and the operational excellence that exists at NIRC," Wery said. "It was important for us to be located at a facility with multiple research capabilities that could harmonize well with the various efficacy and model development studies conducted by CrownBio. We are confident Louisiana, and NIRC, is the place for CrownBio to grow as we engage in the next leading phase of CVMD research that brings drugs to the clinical phase. We are very excited to contribute positively to the economic growth of the New Iberia region."  The UL research center in New Iberia will enable CrownBio to expand its research and grow beyond the capacity it had in North Carolina, company officials said. The company will begin operating at the New Iberia Research Center in January and grow its research services in Louisiana over the next several years. On Jan. 5, the NIRC will host an event welcoming Crown Bioscience to Louisiana. "Our center in New Iberia has the research and analytical expertise and infrastructure in place to assist CrownBio to respond to the needs of its global clientele very quickly," said NIRC Director François Villinger. "We are committed to incubating and growing businesses in the biomedical arena, supported by the strength of UL Lafayette's research in life sciences."  The Iberia Industrial Development Foundation, One Acadiana and LED began working with Crown Bioscience on a potential project earlier this year. In addition to negotiating a facility lease at the New Iberia Research Center, the economic development partners provided project guidance and assistance that will include the company's utilization of the state's Quality Jobs Program.  "We are excited that CrownBio has chosen to invest in Iberia Parish at the New Iberia Research Center," said Iberia Parish President M. Larry Richard. "We are certain that great business investments like this will go a long way to grow and diversify economic opportunities for our citizens."  "Crown BioScience is a respected, growing company whose cutting-edge programs in disease research are well-known, and we appreciate their decision to invest in Iberia Parish," said President and CEO Mike Tarantino of the Iberia Industrial Development Foundation. "The NIRC has long played an integral role in global medical research and development, and we are certain that this partnership will ultimately result in greater success for both Crown BioScience and the NIRC, as well as Iberia Parish. This is yet another indication that Iberia Parish is open for business."  "This announcement exemplifies the Acadiana Region's continued effort to diversify our economy to provide new high-wage jobs for Acadiana families," said President and CEO Jason El Koubi of One Acadiana. "The University of Louisiana at Lafayette's New Iberia Research Center is a tremendous asset for the region, and this partnership demonstrates how we are leveraging Acadiana's cutting-edge research and engineering capabilities to grow our economy."    

NIH停止供养科研用黑猩猩引发争议 来源:科学网 2007-06-07 09:21无忧购全程保障交易安全,实验满意再付款  生物谷援引:美国国立卫生研究院(NIH)近日宣布,考虑到终身照料的庞大费用,该机构将永久性地停止供养科研用黑猩猩。动物权益保护者对NIH的这一决定表示赞扬,而一些科学家则担心这一举措会对生物医学研究产生显著的负面影响。根据NIH国家研究资源中心(National  Center  for  Research  Resources,简称NCRR)的一份声明,NIH"承认黑猩猩在生物医学研究中的持续重要性",但却不能继续承担动物终身照料的费用。由于黑猩猩是唯一能够和人类一样感染C型肝炎病毒的动物,因此,它们最重要的作用就是协助C型肝炎的疫苗研制和疗法研究。此外,黑猩猩还被用于开发单克隆抗体,治疗一些自体免疫疾病,比如狼疮、肠炎、风湿性关节炎等目前全美国大约有1000只研究用黑猩猩,其中一半归NCRR有,分布在全国4家研究机构之中。1995年暂行延期付款(moratorium)以来,NCRR就没有在经费上支持这些黑猩猩的抚养。而在新的决议中,这一制度被永久化了。不过,NCRR还是会继续拨款抚养现有的黑猩猩。2000年,国会通过了《黑猩猩健康改善、维持和保护法案》(Chimpanzees  Health  Improvement,  Maintenance,  and  Protection  Act),要求研究用黑猩猩在"退休"后进入看护所,而不能被施以安乐死。然而,因为黑猩猩的寿命可长达50年,它们一生的养护费用可高达50万美元。NIH的决议受到"美国人性社会"、Project  R&R等动物权益保护组织的热烈欢迎,这些组织以结束科学研究中使用黑猩猩为目标。一些科学家对于NIH的最新决定表示乐观,他们认为这对生物医药研究影响甚微。新伊比利亚研究中心(New  Iberia  Research  Center)主任Thomas  J.  Rowell认为,制药和生物技术公司将介入并为下一代研究用黑猩猩提供资金支持。不过,另外一些科学家并不这样认为。美国国家敏感症和传染病研究所(National  Institute  for  Allergy  and  Infectious  Diseases)的Robert  H.  Purcell表示,科研需要足够的遗传多样性,尽管目前的黑猩猩数量还算充足,但如果NIH在未来没有相应的支持计划,那么这种状况不会持久。美国西南国家灵长类动物研究中心(Southwest  National  Primate  Research  Center)主任John  VandeBerg估计,每年要新生59只黑猩猩才能满足未来的研究需要,而目前美国全国每年出生的研究用黑猩猩只有1015只。此外,VandeBerg表示,"我不相信会有其他组织机构介入,制药公司并不愿意进行长期的投资。某些种类的生物医学研究势必会被削弱。"不过,美国Jackson实验室科学家、NCRR黑猩猩管理计划工作小组的Barbara  Knowles表示,只要黑猩猩的养护者能够制定出新的商业计划,科学研究并不会受到很大的损害。她说,应该重新考虑经费支持的方式了,养护者必须找到经费的合适来源。     

Gains to limit animal research and testing in 2016  December 27, 2016  At The HSUS and Humane Society International, as part of our commitment to all animals, we put our shoulder into the moral and scientific problems of using animals in research and testing. In doing this work, we follow the framework of the Three Rs – refining, reducing, and replacing the use of animals. That approach resonates with so many researchers, since no one should want to use animals if there are alternatives. There's a consensus that hurting animals in research and testing is a moral problem, and we can get past it entirely if there are alternative methods and other strategies that work, and are actually superior, in their place  Today, I run down some of our most important gains in this realm, and note that so much work lies ahead. 

NIH announces plan to retire chimps:  In August, the National Institutes of Health released an official plan for the retirement to permanent sanctuary of hundreds of government-owned and -supported chimpanzees. The development followed prior NIH announcements that it was getting out of the business of using chimps in invasive experiments. The decision to end decades of invasive government-funded experiments on chimps came after expert deliberations concluded with a declaration that chimpanzees are no longer necessary for biomedical research, given the development and recognition of alternative methods and approaches. It also followed a momentous 2015 decision by the U.S. Fish and Wildlife Service, in response to an HSUS-led petition, to close the gate on invasive chimp experiments by listing captive chimpanzees as endangered under the Endangered Species Act, providing them the same level of protections as wild chimpanzees. 

Work to support chimpanzees abandoned by New York Blood Center in Liberia gains momentum:  Since 2015, The HSUS and HSI, with the support of the government of Liberia and others, have been taking care of a group of more than 60 chimpanzees abandoned on a series of islands in Liberia, without food and water, by the New York Blood Center. In 2016, as the chimps continued to thrive under our care, we announced a collaborative campaign with former New Mexico governor and U.N. ambassador Bill Richardson to secure a safe future for the chimpanzees. The Richardson Center for Global Engagement is committed to holding the Blood Center accountable for its responsibility to chimpanzees but also to provide support for proper sanctuary of the beleaguered chimps until that responsibility is reclaimed. Insurance giant MetLife said it was ending its support for the New York Blood Center until the company resolves its dispute with The HSUS and other groups over the medical charity's abandonment of the chimps. Citibank, after learning the facts of the case, took a similar action, disassociating itself from NYBC and then donating $50,000 to The HSUS to be used to care for the chimps. A number of celebrities, including sisters, actresses, and New York natives Kate and Rooney Mara, stepped up to draw the world's attention to the plight of the chimps and to demand that NYBC work with The HSUS to ensure their care. The EPA is moving away from its long-standing requirement for pesticide manufacturers to perform dozens of tests on dogs, rabbits, rats, mice, and guinea pigs, including six extremely cruel tests – perversely nicknamed the "six-pack" – carried out on more than 500 new pesticide products brought to market each year in the United States alone. The EPA is moving away from its long-standing requirement for pesticide manufacturers to perform dozens of tests on dogs, rabbits, rats, mice, and guinea pigs.

Project Chimps partners with New Iberia Research Center with plans to retire 200 chimpanzees:  In May, a partnership agreement was announced between Project Chimps—a new sanctuary in northern Georgia backed financially by The HSUS and other parties—and the University of Louisiana at Lafayette's New Iberia Research Center laboratory to retire 220 chimpanzees. NIRC had been the subject of an HSUS undercover investigation in 2009, and the transfer of these chimps was a remarkable conclusion to a saga that included hundreds of steps to get to this point where invasive experiments have ended and the chimps are on their way to a new life. In September, nine chimpanzees from NIRC safely arrived at Project Chimps, starting the process of moving all of the 220 chimps from laboratories to sanctuaries. The HSUS provided the capital to buy the land for Project Chimps, and we're proud to be so deeply immersed in this project. 

Obama Administration upgrades Toxic Substances Control Act:  In June, President Obama signed into law a bill that upgrades the Toxic Substances Control Act, a 40-year-old federal law regulating the use of chemicals. The bill contains – for the first time in any broader environmental and health protection statute – an explicit decree from Congress to minimize animal testing and to create a clear preference for the development and use of alternative methods and strategies. This will accelerate the movement away from animal tests for safety substantiation of chemicals, as well as pesticides, biocides, cosmetics, and other regulated substances. 

EPA will phase out obsolete animal testing practices in favor of alternatives:  The EPA is moving away from its long-standing requirement for pesticide manufacturers to perform dozens of tests on dogs, rabbits, rats, mice, and guinea pigs, including six extremely cruel tests – perversely nicknamed the "six-pack" – carried out on more than 500 new pesticide products brought to market each year in the United States alone. Following negotiations with The HSUS and other stakeholders, the EPA, in November, announced a plan to allow pesticide manufacturers to waive acute dermal toxicity tests for pesticide formulations. The Organization for Economic Cooperation and Development, a group of 34 member nations, approved four new non-animal test methods to assess the safety of chemicals, and a guidance document that describes how to reduce animal use for acute or lethal toxicity tests. 

Ending cosmetics testing worldwide:  We have seen a cascade of successes in ending cosmetics testing worldwide, since HSI and The HSUS launched our  BeCrueltyFree campaign in 2012. Today, 1.7 billion people, or one quarter of the world's population, live in countries where the sale of animal-tested cosmetics is banned. Thanks to our BeCrueltyFree campaign, we worked to ban animal testing for cosmetics in Taiwan in 2016, while South Korea has made it a legal requirement for companies to use animal testing alternatives where available, and the Australian government pledged to ban cosmetics animal testing and trade in the coming year. Many other countries, including Canada, Brazil, Argentina, Japan, and Russia, are considering bans on animal-tested cosmetics. Here, in the United States, the Humane Cosmetics Act was introduced in Congress. So far, 195 companies in the cosmetics industry have endorsed the legislation. 

USDA imposes record penalty for animal abuse in testing:  In May, the U.S. Department of Agriculture and Santa Cruz Biotechnology – one of the world's largest suppliers of antibodies for biomedical research — came to a $3.5 million settlement agreement, the largest in the 50-year history of the enforcement of the Animal Welfare Act. Over the years, the USDA found serious violations of the law at this laboratory, including numerous severely sick and injured animals, inadequate veterinary care, failure to avoid and minimize pain and distress, and failure to consider alternatives to procedures involving animal pain and distress. SCBT lost its license to operate as a dealer, as well as its registration to operate as a research facility with the USDA, essentially shutting the business down. 

New York passes law to find homes for dogs, cats used in biomedical research:  New York Governor Andrew Cuomo signed a law to require that publicly-funded institutions of higher education give dogs and cats used in biomedical research and testing a second chance at adoption into forever homes—a lifeline for hundreds of dogs and cats in state-funded institutions.  In the year ahead, we'll be pushing for the United States to ban cosmetic testing by enacting the Humane Cosmetics Act, we'll continue our efforts to get all chimps out of labs, and we'll drive ahead our campaigns to replace animal testing with non-animal methods throughout the world.

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