糖尿病治疗药物GLP-1 medication恶心呕吐解药: vitamin B-12 !!!

Common type 2 diabetes drug could be mixed with vitamin B to stop medication causing nausea and vomiting, finds study By SAM BLANCHARD FOR MAILONLINEPUBLISHED: 18:10 BST, 17 July 2018 | UPDATED: 21:30 BST, 17 July 2018 People with Type 2 diabetes cannot properly regulate the levels of sugar in their blood because their body does not use the hormone insulin normally. GLP-1 medications mimic the hormones in a non-diabetic person's body to prevent patients' blood sugar getting too high. Up to 50 per cent of people on medication get nausea They are widely prescribed but cause nausea and vomiting in as many as half of people who take them. The condition means the body does not react properly to insulin – the hormone which controls absorption of sugar into the blood – and cannot properly regulate blood glucose levels. Excess fat in the liver increases the risk of developing type 2 diabetes as the buildup makes it harder to control glucose levels, and also makes the body more resistant to insulin. This, the researchers say, is a reason many people stop taking medications, which can increase their risk of deadly complications from the condition. 'Drug regimens often have long lists of side effects which negatively impact treatment,' said Bart De  Jonghe of University of Pennsylvania School. Side effects stop people from taking their medicine' In Type 2 diabetes, nausea and vomiting top that list. It's the main reason people stop taking their diabetes medications, and diminishes quality of life for millions who do take them. 'In the study the scientists found attaching vitamin B-12 stopped the drug triggering the part of the brain which causes vomiting. Some 90 per cent of shrews which took the unmodified drug were sick, but only 12 per cent of those that were given the vitamin-combined drug vomited. Shrews were used for the study because mice and lab rats are unable to throw up. Dr De Jonghe added: 'The vomiting results are striking and very encouraging. 'It's rare to see such positive results with a new drug compared to the standard. It's hard to not be optimistic.' Type 2 diabetes is closely associated with obesity and other risk factors include genetics, being over 40 years old, or being of of south Asian, Chinese, African Caribbean or black African origin.