Vitamin C, E, ferulic acid speed post-laser wound healing(HealthDay)—Laser-assisted delivery of vitamin C, E, and ferulic acid can decrease postoperative recovery time in fractional ablative laser resurfacing for photo damage, according to a study published online Nov. 27 in Lasers in Surgery and Medicine. Jill S. Waibel, M.D., from the Miami Dermatology and Laser Institute, and colleagues conducted a randomized split face trial in 15 healthy men and women aged 30 to 55 years. Patients were treated with vitamin C, E, and ferulic acid topical formula on one side of the face and vehicle on the other side within two minutes after fractional ablative carbon dioxide laser surgery and during healing. Patients were assessed daily on days one to seven. The researchers observed decreased edema on postoperative day seven for postoperative vitamin C, E, and ferulic acid delivery versus vehicle; decreased erythema was seen on postoperative days three and five. Compared with vehicle control, on the lesion treated with vitamin C, E, and ferulic acid there was significantly increased expression of basic fibroblast growth factor on day five. "This is first study to show that vitamin C, E, and ferulic acid correlate with more rapid wound healing post-fractional ablative laser," the authors write.
Laser-assisted delivery of vitamin C, vitamin E, and ferulic acid formula serum decreases fractional laser postoperative recovery by increased beta fibroblast growth factor expression. Lasers Surg Med. 2015 Nov 27. BACKGROUND AND OBJECTIVE: Laser-assisted drug delivery is an emerging technology to achieve greater penetration by existing topical medications to reach desired targets in the tissue. The objective of this research was to study whether laser-assisted delivery of Vitamin C, E, and Ferulic immediately postoperatively of fractional ablative laser could improve wound healing. Secondary objectives were to evaluate the potential molecular markers involved in this wound-healing process. STUDY DESIGN/MATERIAL AND METHODS: A double blinded, prospective, single center, randomized split face trial of Vitamin C, E, and Ferulic topical formula #740019 to decrease postoperative recovery time in fractional ablative laser resurfacing for photo damage. Fifteen healthy men and women of ages 30-55 years were treated with the Vitamin C, E, and Ferulic acid serum to one side of face and vehicle to the other side of face, within 2 minutes immediately after fractional ablative CO2 laser surgery and daily during the healing process. Patients were evaluated daily on days 1-7 using photographs, patient questionnaires, and molecular evaluation. RESULTS: Clinically, postoperative Vitamin C, E, and Ferulic delivery resulted in decreased edema versus vehicle on postoperative day 7 and decreased erythema versus vehicle on postoperative days 3 and 5. Molecularly, the expression of basic fibroblast growth factor (bFGF) was significantly increased at day 5 on the lesion treated with Vitamin C, E, and Ferulic acid serum compared to vehicle control on the other side. CONCLUSION: This is first study to show that Vitamin C, E, and Ferulic acid correlate with more rapid wound healing post-fractional ablative laser. Elevated bFGF could be involved in the Vitamin C, E, and Ferulic acid-induced rapid wound healing. Lasers Surg. Med. © 2015 Wiley Periodicals, Inc.
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