Strawberry extracts actively stimulate proteins that offer protection against cardiovascular disease Published on July 4, 2012 Strawberries, the traditional summer treat
associated with Wimbledon could be serving up
some unexpected health benefits. Scientists at the University of Warwick
have been studying the beneficial effects of strawberries on our cardiovascular
health, particularly around how they prevent the development of heart disease
and diabetes. Professor Paul Thornalley from Warwick Medical School heads the
team that discovered extracts from strawberries positively activate a protein
in our bodies called 'Nrf2' which is shown to increase antioxidant and other
protective activities. This protein works to decrease blood lipids and
cholesterol, the very things which can lead to cardiovascular problems. Eating
strawberries has previously been found to counter post-meal blood glucose and
low density lipoprotein, or 'bad' cholesterol and therefore decrease risk of
diabetes and heart disease, but this is the first time that strawberry extracts
have been proved to actively stimulate proteins that offer us protection
against disease.
Professor Thornalley explained: "We've discovered the science behind
how strawberries work to increase our in-built defences to keep cells, organs
and blood vessels healthy and which can reduce the risk of developing
cardiovascular problems such as heart disease and diabetes. "So don't feel
guilty about serving up strawberries and cream … although I'd suggest more
strawberries and less or even no cream!" Screening and mathematical
modelling techniques developed at the University of Warwick can now take this
research further to help identify the best varieties of strawberries, how they
are served or processed and how many strawberries should be eaten for optimum
health benefit.
Source: http://www2.warwick.ac.uk/newsandevents/pressreleases/strawberry_wimbledon-superfruit
Nuclear factor (erythroid-derived 2)-like 2, also known as NFE2L2 or Nrf2, is a transcription factor that in humans is encoded by the NFE2L2 gene.NFE2L2 induces the expression of various genes including those that encode for several antioxidant enzymes, and it may play a physiological role in the regulation of oxidative stress. Investigational drugs that target NFE2L2 are of interest as potential therapeutic interventions for oxidative-stress related pathologies.
Gene expression pattern of the NFE2L2 gene.
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